Prof. Dr. rer. nat. Katja Siebecke née Ferenz

Professor, Faculty of Medicine, University of Duisburg-Essen, Essen University Hospital

Associated Professorship

Physiology

Vita

University training and advanced academic qualifications

• 2008 - 2010, Dissertation (Dr. rer. nat.) University of Muenster, Muenster, Germany, with Prof. Dr. Dr. J. Krieglstein, Institute of Pharmaceutical and Medicinal Chemistry
• 2002 - 2008, Pharmacy, Universities of Marburg and Muenster, Germany; Université Paris-Sud, France.

Postgraduate professional career

• Since 02/2018, Assistant Professor, Institute of Physiology, University of Duisburg-Essen, Essen, Germany
• 2011 - 2018, Postdoctoral Fellow, Institute of Physiological Chemistry, University of Duisburg-Essen, Essen, Germany with Prof. Dr. Dr. H. de Groot
• 2010 - 2011, Postdoctoral Fellow, Institute of Pharmaceutical and Medicinal Chemistry, University of Muenster, Germany with Prof. Dr. Dr. J. Krieglstein

Focus of Work

Synthesis and Application of Perfluorocarbon-Based Artificial Oxygen Carriers as an Alternative to Red Blood Cell Concentrates

Research and Practice projects (selection)

Publications (selection)

I Originalartikel

• Semmler A, Köhler J, Regolien L, Bayer F, Polyansky N, Gradhand E, von Knethen A, Zacharowski K, Nocke F, Ferenz KB, Schwäble J, Bonig H, Herrmann E, Hornung I, Steinicker AU (2024). Selective red blood cell depletion by apheresis in sheep causes severe normovolemic anemia. Current Research in Translational Medicine: Available online 17 August 2024, 103463, doi.org/10.1016/j.retram.2024.103463
• Rother T, Horgby C, Schmalkuche K, Burgmann JM, Nocke F, Jägers J, Schmitz J, Bräsen JH, Cantore M, Zal F, Ferenz KB, Blasczyk R, Figuereido C (2023). Oxygen carriers affect kidney immunogenicity during ex-vivo machine perfusion. Front. Transplant. 2:1183908. doi: 10.3389/frtra.2023.1183908
• Pizanis N, Dimitriou AM, Koch A, Lüdike P, Papathanasiou M, Rassaf T, Ruhparwar A, Schmack B, Weymann A, Ferenz KB, Kamler M (2023). Introduction of machine perfusion of donor hearts in a single center in Germany. IJC Heart & Vasculature 47: 101233
• Hester S, Ferenz KB, Adick A, Kakalias C, Mulac D, Azhdari S, Langer K (2023). Triglyceride-filled albumin-based nanocapsules: A promising new system to avoid discarding poorly water-soluble drug candidates. International Journal of Pharmaceutics 646: 123454
• Jaegers J, Haferkamp S, Arnolds O, Moog D, Wrobeln A, Nocke F, Cantore M, Pütz S, Hartwig A, Franzkoch R, Psathaki OE, Jastrow H, Schauerte C, Stoll R, Kirsch M and Ferenz KB (2022). Deciphering the Emulsification Process to Create an Albumin-Perfluorocarbon-(o/w) Nanoemulsion with High Shelf Life and Bioresistivity. Langmuir 30;38(34): 10351-10361
• Jägers J, Kirsch M, Cantore M, Karaman O and Ferenz KB (2022). Artificial oxygen carriers in organ preservation: Dose dependency in a rat model of ex-vivo normothermic kidney perfusion. Artif Organs 46(9): 1783-1793
• Hester S, Ferenz KB, Eitner S, Langer K (2021). Development of a Lyophilization Process for Long-Term Storage of Albumin-Based Perfluorodecalin-Filled Artificial Oxygen Carriers. Pharmaceutics 13(4): 584
• Wrobeln A, Jägers J, Quinting T, Schreiber T, Kirsch M, Fandrey J and Ferenz KB (2020) Albumin-derived Perfluorocarbon-based Artificial Oxygen Carriers Can Avoid Hypoxic Tissue Damage in Massive Hemodilution. Scientific reports 20;10(1): 11950
• Mayer D, Guerrero F, Goanvec C, Hetzel L, Linders J, Ljubkovic M, Kreczy A, Mayer C, Kirsch M and Ferenz KB (2020). Prevention of Decompression Sickness by Novel Artificial Oxygen Carriers. Med Sci Sports Exerc 52(10): 2127-2135
• Wrobeln A, Schlüter KD, Linders, J, Mayer C and Ferenz KB (2017). Functionality of albumin-derived perfluorocarbon-based artificial oxygen carriers in the Langendorff-heart. Artif Cells Nanomed Biotechnol 45(4): 723-30
• Wrobeln A, Laudien J, Groß-Heitfeld C, Linders, J., Mayer C, Wilde B, Knoll T, Naglav D, Kirsch M and Ferenz KB (2017). Albumin-derived perfluorocarbon-based artificial oxygen carriers: A physico-chemical characterization and first in vivo evaluation of biocompatibility. Eur J Pharm Biopharm 115: 52-64
• Ferenz KB, Rose K, König S and Krieglstein J (2011). ATP-NGF-complex but not NGF is the neuroprotective ligand. Neurochem Int 59(7): 989-95

II Übersichtsartikel

• Jägers J, Wrobeln A and Ferenz KB (2020). Perfluorocarbon based oxygen carriers: From Physics to Physiology. Pflugers Arch. 473(2): 139-150
• Leu T, Schützhold V, Fandrey J and Ferenz KB (2019). When the Brain Yearns for Oxygen. Neurosignals 27(1):50-61
• Mayer D and Ferenz KB (2019). Perfluorocarbons for the treatment of decompression illness: How to bridge the gap between theory and practice. Eur J Appl Physiol 119 (11): 2421-2433
• Ferenz KB and Steinbicker A (2019). Artificial oxygen carriers- past, present and future-a review of the most innovative and clinically relevant concepts. J Pharmacol Exp Ther 369: 300-10
• Scheer A, Kirsch M and Ferenz KB (2017). Perfluorocarbons in photodynamic and photothermal therapy. J Nanosci Nanomed 1(1): 21-27
• Ferenz KB (2015). Künstliche Sauerstoffträger-wie lange müssen wir noch warten? Hämotherapie 25: 27-36

III Bücher/Buchbeiträge

• Ferenz KB, Karaman O, Shah SB, Chapter 17: Artificial Red Blood Cells, in Nguyen TA (Ed) Nanotechnology for Hematology, Blood Transfusion, and Artificial Blood, Micro and Nano Technologies, Elsevier 2022, pages 397-427, doi.org/10.1016/B978-0-12-823971-1.00018-0
• Ferenz KB, Chapter 08: Artificial oxygen carriers in Basile A (Ed) Membrane applications in the Artificial Organs and Tissue Engineering, Elsevier 2020, pages 191-213, doi 10.1016/C2017-0-00160-X

IV Patente

• Ferenz KB, Nocke F, Stoll R, Schauerte C, Haferkamp S, Kirsch M, Metzger J, Jägers J, Cantore M, Arnolds O, Pütz S (2021). DE-102021211272.2, filed on 06.10.2021, “organ life fluid“-Zusammensetzung enthaltend künstliche Sauerstoffträger zur Verhinderung von Organschäden in Transplantationsorganen
• Ferenz KB, Nocke F, Steinbicker AU (2022). EP-22193221.3, filed on 31.08.2022, Lecithin‐modifizierte nanoskalierte Sauerstoffträger (LENOX)

Websitelink to my Publications

Keywords

artificial oxygen carriers, organ machine perfusion, artificial blood

Casegroup

Medicine and Health